I used to run purigen all the time, but eventually stopped. Didn't seem to do a lot, so the effort didn't seem to be worth it. It always slowly turned brown, so I knew it was working, and I would recharge it after so long, but it became a pain. With very little to show for it. I think a skimmer probably removes much more DOC than a small bag of purigen ever would. it works too slowly to be an effective means of nutrient removal in my opinion.
My tank leans more towards low nutrient issues rather than high nutrient issues, so I stopped using it. I really didn't need it.