First off, order bio-spira from Dr. foster and smith. They actually send you a cold bottle with insulation to retain freshness. Second, the liquid will create excessive bubbles with the skimmer and can cause overflowing. But, lets also go back to the point of the skimmer, which is to remove organics from the water column. Which, it's a new tank and therefore doesn't have much for organics. Also the instruction to wait 48 hours before skimming is in reference to an already established tank. Basic rules to cycling, we should wait 30 days. You want things to "fester" to build a strong bacterial environment. At least that is how I approach it.
