Hard to tell without seeing your rockscape, but in general I'd do one on each short side pushing to the center of the tank, and two on the back long side pushing forward - that would give you some good variability in current direction. You'll have to adjust the percent flow according to your aquascape and corals. Typically in this configuration, the pumps on the short side pushing along the long axis of the tank are set at a good bit higher flow than those on the back wall. So you could do probably get away with mp10's on the back wall if you wanted to save some money. If you are getting sand, get some with large enough grains that won't be blown away. I like the look of the 2-3mm sand, but put larger grains around the edges (some people have to go with large stuff like CA reactor media) so it won't be blown around. Just know that flow is not a set it and forgot it parameter, so as your corals grow - their skeletons will change the flow in the tank (often inhibit it), so over time you may need to move powerheads, turn them up, etc.