Thank you for a good write up
@Brew12 . It could not be a surprise for anyone that I have the same standpoint as you according to prophylactic treatment. This morning - before I read your article - I read two treads that got me wonder if not the prophylactic methods kill more fish than the real diseases does?
Let us first state – I am not against an observing QT – not at all – many times it could be very important to run a observing QT and treat only if signs of diseases show up. So, let us leave that type of argues – it is true that I do not use QT in my tank, but I have a strict way of acclimating my fishes in my refugium. The reason why I do not even use an observing QT is that I have a mature reef with many hungry mouths.
I have – in the past, bread a grow many of the most aggressive African Cichlid species that exist and one thing I learned when I did that was that if I want to introduce new fishes to my aquaria – keeping them in the same water as the DT (or in the last weeks before introduce them from another aquaria doing daily WC with the DT water) . I did this out of sight for the DT inhabitants but when I introduce the newcomers – it was very seldom fighting at all. The only reason for this – IMO – is that they through the WC got the same smell.
I was among the first people to develop a strategy into use of metradizonole in order to fight African bloat. My first experiments were done around 1977 and soon it become a standard treatment method for this disease in Sweden. However – I did never use it as a prophylactic. Around 1983 – the first examples of African Bloat that could not be treat by metradizonole appear. It was mainly grazers (algae eaters) that was attacked by these flagellates and when people change the feeding regime to algae food – much of the problems disappear. By the way – metradizonole is a lipophilic drug – this means that it will move itself into fat – and even if it can´t be dissolved in water – it will enter the fish bloodstream through the gills and even through the skin. And it will bioaccumulate – it means – even if the concentration in the water is low – it will be much more concentrated in the fish. And – according to saltwater fish – they drink and you will have a double pathway into the fish – oral and through the tissues. The lipophilic properties will also make the degradation and excretion problematic and it will go by the MFO system. The fact that SW fish do not pee very much will not get the excretion better. IMO – the normal recommend acute dosage for both metradizonole, chloroquine phosphate, and praziquantel (all strongly lipophilic) is way to high for SW fishes.
Sincerely Lasse