I run a 220 with 3 3” yellow, a 3” purple, a small kole eye, 2 browns, and until last week a 5-6” orange shoulder and 6” inch sail fin. When I added the three yellows, only two were aggressive, and that was towards each other. The purple never paid any attention to the yellows. I run a lot of live rock in the tank and in the 200 gal sump. The live rock and extensive aqua scape provide plenty of diversion and hiding places. The reason I moved the big guys out was that it is an SPS dominant tank, and I am still learning how to grow the buggers. The two large fish kept knocking over the corals, complicating the already challenging process. The point is: just like raising kids, keep them occupied and interested with new tank mates and scapes, add the new guys at night, (well, making new ones is fun any time of the day or night), and be ready to adjust when relationships change. Like anything else, if you have time and observe, you can adjust almost anything.