Anyone have experience with FixICK ?

mattzang · Aug 11, 2020

ScottR said:
Haven’t used this product but Two Little Fishes Revive coral dip has “citrus limon” in it. Which is basically lemon. Not sure if they’re using an extract like D-limonene. The bottle says it contains 0.5% but it has a very strong lemony scent so I’d assume it’s some sort of extract. I dip everything that goes in my tank and haven’t encountered ich yet. Fingers crossed. Oldest fish are almost 2 years old and I didn’t QT them. Is lemon the secret cure?

you dipped your fish in revive?

vetteguy53081 · Aug 11, 2020

Revive is for coral and not fish and can be lethal to fish - hope you meant coral

ScottR · Aug 11, 2020

mattzang said:
you dipped your fish in revive?

No no haha. Every coral that went in got dipped.

ScottR · Aug 11, 2020

vetteguy53081 said:
Revive is for coral and not fish and can be lethal to fish - hope you meant coral

It says on the bottle it’s for corals and anemones only but it does say “not intended for fish meant for human consumption”. Strange wording.

ichthyoid · Aug 11, 2020

pdxmonkeyboy said:
Can you perhaps explain the phrase " Protein prenylation in eukarytic cells" First I thought oh.. it is some kind of lipid productiin inhibitor but that phrase makes me think that only some organisms have this prenylation and that is why it targets them?

I got an A in anatomy physiology but a C in O chem. That was over 20 years ago though. Its kind of funny, i remember a video about photosytheis in 3rd grade. It was a cartoon and the charecters hid behind a curtain because at the time they didn't know how exactly the process worked. Lol

Prokaryotes are simpler types of cells which lack a true nucleus and other specialized organelles, while eukaryotes are more highly developed & have those structures.

Prenylation is a modification to cellular proteins in which lipid chains (isoprenes) are attached giving them hydrophobic segments. This affects their location & function within the cell structure.

This modification may help regulate signal transmission or chemical transport, for example. Disruption of these structures may derugulate and/or interrupt those processes.

Fwiw,
Some gardeners (me included) spray d-Limonene solution on weeds which disrupts the lipid cell membrane, causing dehydration & death & it’s ‘organic’.

Prenylation (Molecular Biology)

Prenylation or isoprenylation is a post-translational modification process in which cysteine residues close to the C-terminal regions of some eukaryotic proteins are biosynthetically modified with an isoprenoid lipid: the 15-carbon farnesyl group or the 20-carbon geranylgeranyl group (see Fig. 1 […]

what-when-how.com

I love o-chem, physics too, equally

pdxmonkeyboy · Aug 13, 2020

Well, thought i would post an update. Its day 4? And no signs of any infection. It is day 3 of the treatment so big water change and redose tomorrow.

pdxmonkeyboy · Aug 18, 2020

So another update. I have dosed the tank a total of five times. I did three doses, then took 3-4 days off because I ran out of salt. Did a 40% water changed and dosed once a day for the last two days.

Still no signs of ich or ich like behavior. So I guess now comes the question.. Do I risk transferring the fish to my DT that I know is ich free? Maybe keep them in isolation/observation a little longer?

Mattiejay6 · Aug 18, 2020

well is there any rush to move them into the aquarium? I would observe them for 2 more weeks.. also I recently discovered people use black mollies as guinea pigs.. put them in the tank and see if the contract the white dots.

AbjectMaelstroM · Aug 18, 2020

Following along, for science!

pdxmonkeyboy · Aug 18, 2020

Of course there is a rush...new fish!! I may pick up a 6 pack of mollies and see what happens.

AbjectMaelstroM · Aug 19, 2020

Might be a good read, credit goes to @Humblefish for digging it up.

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onlinelibrary.wiley.com

Basically confirms that it's nothing really revolutionary and has been used since as far back as the 1930s. The fact that it's banned for use in fish for human consumption is interesting. Also it seems as if it's targeted more towards tearing FW variants (raising temp is commonly used in FW to help with parasites).

I guess we will see, looking forward to your results. But I don't think I'll be throwing my stash of chloroquine phosphate quite yet.

h2so4hurts · Aug 19, 2020

pdxmonkeyboy said:
So another update. I have dosed the tank a total of five times. I did three doses, then took 3-4 days off because I ran out of salt. Did a 40% water changed and dosed once a day for the last two days.

Still no signs of ich or ich like behavior. So I guess now comes the question.. Do I risk transferring the fish to my DT that I know is ich free? Maybe keep them in isolation/observation a little longer?

How do you know they're crypto free? The max incubation time between cycles is 8 days. Minimum treatment time with methods that have proven efficacy is 14 days with an additional 14 days of observation.

AbjectMaelstroM · Aug 19, 2020

I would wait at least two weeks after completion of the treatment cycle before you add them to your DT.

+1 for black mollies. I have them in my Coral QT for that reason.

pdxmonkeyboy · Aug 19, 2020

I don't know they are cryto free... nobody can know and i guesss, and that is what i am worried about.

I am going to get some mollies today after work. At the very least it does appear to be working and without the testing or apparant harshness of copper.

I would like to get a fish covered in ich and see how it does.

h2so4hurts · Aug 19, 2020

pdxmonkeyboy said:
I don't know they are cryto free... nobody can know and i guesss, and that is what i am worried about.

I am going to get some mollies today after work. At the very least it does appear to be working and without the testing or apparant harshness of copper.

I would like to get a fish covered in ich and see how it does.

I wouldn't draw that conclusion at all until they've been spot free for a month. Crypto is well known for reappearing after a week or so of being "cured."

pdxmonkeyboy · Aug 19, 2020

I realize this. I have had fish carry ich for a year and not show it until a new, large, and aggressive fish was added.

I am toying with the idea of having the tank water tested for the presence of cryptocaryon genetics. I did not see any tormonts when I added the fish to the tank, nor have I seen any since.

Mattiejay6 · Aug 20, 2020

@pdxmonkeyboy here is a blurb from humble.fish on the mollies.

“ A freshwater black molly will have no immunity whatsoever to marine diseases, thus making it probable for visible symptoms to show. And evidence of ectoparasites (e.g. ich, velvet, brook) will show up as white spots on a black molly or translucent if a tankmate has flukes.”