If that's the only filtration you're going to be adding, it might become tough, and a tank crash would porbably be inbound. Of course that depends on the inhabitants of the aquarium. What were you going to fill your tank with again?
I was planning a 200 gallon refugium myself, but I felt it overcomplicated things a bit, though I might still go ahead and get one. I've heard many experienced hobbyists saying that algae scrubbers have made all their other filtration become almost obsolete, with the remaining filtration either used as a backup or used just to make the water look nice (though algae filters can accomplish this).
150 gallon refugium sounds tiny compared to a 1600 gallon tank. I'm thinking that you could perhaps make use of cleaner clams. They're relatively cheap critters that filter feed on particulates, and, though not suited to reef temperatures, can live for upwards of a year in such environments. Just make sure, however, that you (a) have a cleaner crew that will scavenge them out from the sand if they die, or (b) put them on a tack/off the sand so that they don't die in your sand if you can't do (a). From what I've read, they act like living protein skimmers and have never bombed someone's tank like giant clams do when they die.