I run bio pellets and have never had an issue. I have been running them for about a year and a half. I really dont know why someone would tell you to keep your alk low to run the biopellets, I mean would you keep your alk low to feed nori?? Flake food?? Thats all bio pellets really are, a solid carbon food source for specific strains of bacteria. Too much flow through pellets can cause rtn, cyano, and other issues. This has been corroborated by many other's on RC and other sites it's not just my conclusion but many hobbyists. I found that I never could reduce the flow enough in my reactor so I just took it off line and put them in a filter bag in the sump. My nitrates and phophates still stay zero but I dont have any other issues that can arise with too much flow through the pellets. Some speculate that too much flow sloughs off the carbon and causes rtn, which has also been proven to happen when you tumble activated carbon in a reactor. If you have other questions just pm me.