it gets a little confusing but holding to the original point it wont matter, there is no config that you could use or not use biowheels that would harm a reef tank. even if you didn't ever clean them, they'd be less dirty and impactful to a sw aquarium vs any average sandbed of 2+ yrs age.
the accurate way to think about how the filter bacteria apply to this scenario is using any biowheel at all is so far beyond the tank nitrification surface area requirements, the configuration, flow, speed or rating doesn't apply. use any combo on full blast or dialed down, your measurements w remain the same.
The ammonia that the living animals make inside your tank is in high demand, highest among emitted molecules I can think of. It will be uptaken rapidly upon production, and your biowheels w never see any. having something spinning in the water that is seeking ammonia, and not getting any ever, is harmless. the only impact is adding unneeded surface area creates additional cleaning. some might like the extra oxygenation of surface tension breaking filtration schemes, biowheels are harmless to employ in any way. stacks and stacks of bio balls are equally harmless in the same way.
When someone chooses to design a tank with no retentive sandbed, and very free of detritus, say a true ultra low nutrient acro system, they wont be using these items as detritus really does matter in that design. in 95% of reef tanks, detritus is expected and heartily retained.