I’ve had to do it 4 times and it’s always visually gone within the first 6 days or so, and have never seen it regrowing when treating, are you sure it’s bryopsys growing? I removed the meds from that last treatment (4th treatment in a year) over 3 months ago and I am starting to see a little pop up gonna probably do another mom that long treatment again soon as every time it comes back it’s in less places than before and this time took longer to show back up and in only a couple places. Maybe the 5th time is the charm. Good news is it doesn’t effect any of my corals and I have a highly stocked reef with all kinds of corals, a lot of them being acros.