Bryopsis Cure: My Battle With Bryopsis Using Fluconazole

[stevo01]

Day 11

 

[NCreefguy]

I had those last few stalks that held on but they eventually turned white and melted away.

 

[Rick.45cal]

I see a few in there still hanging on! I wouldn't give it a second dose just yet! I had chunks appearing in my filter socks after I couldn't find any in the tank and they were still green, but it's all gone now.

 

[prsnlty]

Wow good for you! Its a real nightmarr after a while Youll be bryopsis free soon!

Can't wait!

 

[stevo01]

FAQs sheet updated and @NCreefguy pm'd.

 

[stevo01]

I cant wait to make some charts!

 

[Ssindt]

So I found this I hope I didn't add something I shouldn't have. I dosed tablets 2 days ago no change everything seems ok no changes in the bryopsis.

Capsule contain

Ingredients
Active ingredient:

• Fluconazole 50mg - 50mg fluconazole.
• Fluconazole 100mg - 100mg fluconazole.
• Fluconazole 200mg - 200mg fluconazole.

Inactive ingredients:

• lactose
• maize starch
• magnesium stearate
• colloidal anhydrous silica
• sodium lauryl sulfate
• titanium dioxide
• gelatin
• indigo carmine CI73015
• brilliant scarlet 4R CI16255 (200mg capsules only)
• shellac
• black monogramming ink (107581 or 2328)
• propylene glycol.

Tablets contain;


Fluconazole tablets USP contain 50, 100, 150, or 200 mg of fluconazole USP and the following inactive ingredients: croscarmellose sodium, dibasic calcium phosphate anhydrous, FD&C Red No. 40 aluminum lake dye, magnesium stearate, microcrystalline cellulose and povidone.

 

[NCreefguy]

FAQs sheet updated and @NCreefguy pm'd.

Updated

 

[KenO]

So I found this I hope I didn't add something I shouldn't have. I dosed tablets 2 days ago no change everything seems ok no changes in the bryopsis.

Capsule contain

Ingredients
Active ingredient:

• Fluconazole 50mg - 50mg fluconazole.
• Fluconazole 100mg - 100mg fluconazole.
• Fluconazole 200mg - 200mg fluconazole.

Inactive ingredients:

• lactose
• maize starch
• magnesium stearate
• colloidal anhydrous silica
• sodium lauryl sulfate
• titanium dioxide
• gelatin
• indigo carmine CI73015
• brilliant scarlet 4R CI16255 (200mg capsules only)
• shellac
• black monogramming ink (107581 or 2328)
• propylene glycol.

Tablets contain;


Fluconazole tablets USP contain 50, 100, 150, or 200 mg of fluconazole USP and the following inactive ingredients: croscarmellose sodium, dibasic calcium phosphate anhydrous, FD&C Red No. 40 aluminum lake dye, magnesium stearate, microcrystalline cellulose and povidone.

How many gallons of water in your system?
Which size med did you use?

 

[Ssindt]

30 gallon frag tank dosed 200mg per 10g and I got tablets not capsules.

 

[prsnlty]

Ok, I went ahead and did 1 last wc of 27g and began treatment. Here is the starting info:

2/4/17 12:30am
180g twv
Dosed 18-> 200mg capsules
Sg 1.027
ALK 8.9
CA 440
MG 1320
No3 20ppm
P04 undetectable
Temp 77.1
Ph 8.25
0 GAC
0 GFO
Skimmer on no cup
Using filter socks - change daily
Put 1/2 my chaeto back

Will dose 4ml nopox daily, alk, ca, mg and acropower on doser.

Foods I feed randomized:
Reef roids
Reef chili
Frozen cyclops
Frozen mysis
Frozen spirulina brine
Lrs reef frenzy
Hikari sinking pellets marine a
Yaki-nori 1 full sheet (tangs are pigs!)
Fish poo

***All lighting and flow will be normal. Gac and gfo on manifold turned off, skimmer on but no cup and not overflowing. Sump reverse lighting on.

Edit: forgot to mention I use Hannah Phosphate checker (which 0 means .04 or below according to BRS for margin of error)
Salifert for ALK and Red Sea for all other tests. I do have the Red Sea Colors tests as well and was thinking about running those (tomorrow) since it will tell me K, Fe & I2 also.

 

[mcarroll]

Ok, top 20 Q&A. Here it is.

Maybe throw a few elements of conservatism in there just for good luck.

How sure are we about carbon removing the med?

What do we know about disposing of this down the drain?

What do we know about how this breaks down in the tank?

I'm not suggesting those questions for your FAQ, but to suggest that there's still a fair amount of uncertainty since this has only been used by folks for a few weeks AND we don't have answers to those questions. The FAQ is currently a (very good) cheerleader's guide to fluconazole.

Even more words of warning and caution than are in there would be a good idea until more time has passed and more answers are known.

For the FAQ you might want to add: Remove UV sterilizer if used.

I reference this study of the effects of UV light on various brands of fluconazole.
Link

Thanks for posting this! It's the only thing I've seen so far about the breakdown of fluconazol.

Since all our fluconazole (@stevo01 do you know how many kilograms of fluconazole can we account for in our thread so far? Good one for the FAQ! ) is ultimately going down the drain with the water changes, I'm still looking for something that talks about its breakdown wastewater systems and in nature though.

Anyone?

 

[Pongo]

Here's some more light reading about fluconazole and sewage treatment.
Link

 

[prsnlty]

I found this environmental study of the drug http://pubs.acs.org/doi/abs/10.1021/es8009309

 

[prsnlty]

Maybe throw a few elements of conservatism in there just for good luck.

How sure are we about carbon removing the med?

What do we know about disposing of this down the drain?

What do we know about how this breaks down in the tank?

I'm not suggesting those questions for your FAQ, but to suggest that there's still a fair amount of uncertainty since this has only been used by folks for a few weeks AND we don't have answers to those questions. The FAQ is currently a (very good) cheerleader's guide to fluconazole.

Even more words of warning and caution than are in there would be a good idea until more time has passed and more answers are known.



Thanks for posting this! It's the only thing I've seen so far about the breakdown of fluconazol.

Since all our fluconazole (@stevo01 do you know how many kilograms of fluconazole can we account for in our thread so far? Good one for the FAQ! ) is ultimately going down the drain with the water changes, I'm still looking for something that talks about its breakdown wastewater systems and in nature though.

Anyone?

After some research I could only find a few articles on waste water and in lakes. (Other than medical uses and studies). Most versions of fluconazole doesn't break down in treated water bottom line. However it is made up of mostly calcium which might raise ca levels in the aquarium (jmo). Nothing found on carbon remove ability. @Randy Holmes-Farley What are your thoughts? Is there a way to test if carbon would absorb it?

I would say that this method for bryopsis needs to be tested for lowest doses possible to get the same end result if implemented and only as a last resort after all other options are exhausted.

 

[prsnlty]

Something that concerns me is that fluconazole is medically known, that over time, can cause liver and kidney damage in humans. I do wonder how our livestock will handle even the 1 time dosage months later.

 

[mcarroll]

After some research I could only find a few articles on waste water and in lakes.

If any of those articles looked good, I'd appreciate it if you could link them here. Especially if the full article is there....but even if it's just an abstract it can be good.

 

[mcarroll]

(I may not have scrolled up far enough....saw a few links just now!!!)

 

[prsnlty]

If any of those articles looked good, I'd appreciate it if you could link them here. Especially if the full article is there....but even if it's just an abstract it can be good.

The only environmental articles that I found are the ones @Pongo and i linked above aside from medical.

 

[mcarroll]

Here's some more light reading about fluconazole and sewage treatment.
Link

Good one! So fluconazole is exceptional in at least one aspect....it practically does not break down at all in the environment.

I found this environmental study of the drug http://pubs.acs.org/doi/abs/10.1021/es8009309

Definitely not good from an ecological point of view....but not surprising I guess. I bet most drugs are like that.

And it does seem like the environment is already a bit clogged with this med....explains the other research I saw where they were investigating exotic methods to try and break it down.