I have used the cermedia cubes on aquaculture and quarantine systems in the past. Given these systems have very little surface area, just tank walls and plumbing, they were plagued with high ammonia and nitrite readings, after about three weeks both dropped to zero, nitrates are controlled with water changes. So I think they do work for certain implementations but I would not force water through them in any way, rather use them passively in the sump, because they seem to have the structure of a filter sponge you can't ring out. For most reef tanks with sand they are probably unnecessary. People have reported denitrification with the bigger blocks, but the sales rep couldn't really offer much insight into this so its a bit of trial and error. Are they better than bioballs, definitely, but with live rock and sand in a low nutrient input reef tank, I don't know... For fish only tanks and some specialty filtration setups I think they are great.