I had 3 liters of ehiem substrate pro in a mesh bag in my sump for over a year.
You can take them out and rinse in tank water to clean.
I removed them from my 120 after about 18 months with no effect on the system.
Good question and following along as I have thought about this as I design my build. To many posts about metals leaching out of the bio blocks wondering how folks are using the ceramic balls or other and if any negative impacts.