Ok, As I was curious about this as I had used ChemiPure in the past, I did some digging. Turns out that ChemiPure works but the added ion resins are rendered all but mute within a saltwater aquarium. I used to use Seachem Purigen and it worked well for me along with the ChemiPure. Upon further research and evaluation, I believe, cost as a predominant factor, that ChemiPure is not warranted. I think that I will use a high-quality carbon, GFO, and Purigen and see how that all works out. The benefit of Purigen is it is able to be regenerated. There are things that have changed since leaving the hobby many years ago and things that have stayed the same and, more importantly, more evidence-based research on particular products. If all else fails, I can go back to using ChemiPure.