CIPROFLOXACIN: IN CURING ANEMONES.

[dbraun15]

Day 4: morning required an additional change in water... turns out my pump stopped working. It resulted in the water turning almost milky white and the anemone not looking its best, still very responsive to touch but I fear the worst right now...I did the water change this morning and left for work. I also dropped my dosage to 250 mg of Ciprofloxacin.
I am hoping I come home to improved conditions with the new pump running.

Also, be careful when you administer the medication...light degrades the Cipro, so it's recommended that you put medication in before lights out. Hope that helps.

 

[Christopher Davis]

I personally wouldn't stop the meds...continue the treatment. It's not looking good, but IMO, continued doses of medication can only help. How many days have you been treating? I think 7 straight is ideal and don't end treatment early. Good luck!

We are on day 4 today.

 

[Sea MunnKey]

We're all in this to make R2R the BEST & Greatest!!!!

 

[EmdeReef]

I went through the same thing last year with two Blue haddoni's. May I ask where you got it? just wondering if it is the same place? one was dieing before I got it in the tank and the other looked good for a day or two.
Anyway Cipro did not save mine. I am on the fence on if it helps or actually stresses the anemone more. Some people swear it helps. Once they start the decline I see no reason not to treat it though, might save it, might not but without it they die anyway.

Hope it saves yours.

There are 3 antibiotics studied to help, Cipro was deemed most effective but like with people there are many other factors and there can be variations in efficacy between specimens. I’d say it generally helps depending on:

- proper diagnosis
- medication purity (big issue for many fish meds)
- infection stage
- environment

 

[Christopher Davis]

There are 3 antibiotics studied to help, Cipro was deemed most effective but like with people there are many other factors and there can be variations in efficacy between specimens. I’d say it generally helps depending on:

- proper diagnosis
- medication purity (big issue for many fish meds)
- infection stage
- environment

+1

 

[EmdeReef]

Maybe I'm thinking too far ahead BUT wouldn't it be convenient if R2R creates a dedicated "Medication" forum (has to be proven and positive method) with brief description(s) of proper ID of medication etc. involved? And without going into too much in depth details, there would be links to read and learn on top of that?

Makes it a whole lot easier than creating clusters of threads after threads of the same questions but titled differently? Just saying .... don't shoot me ;Blackeye

Livestock: Anemone
Symptom: Gapping mouth syndrome (just a figure of speech ...)
Medication: Ciprofloxacin (Fish Flox)
Where to Buy/Order: Amazon, Ebay, local pharmacy etc.
Quarantine Period: Approximate 10 Days
Read Thread links(s): https://www.reef2reef.com/threads/ciprofloxacin-in-curing-anemones.353347/#post-4394877
Reefer Reviews?: or ;Vomit

Good idea if it can be implemented

 

[EmdeReef]

I personally wouldn't stop the meds...continue the treatment. It's not looking good, but IMO, continued doses of medication can only help. How many days have you been treating? I think 7 straight is ideal and don't end treatment early. Good luck!

I'd generally agree but for 3 considerations to keep in mind: 1) pump failure caused the deterioration not the treatment, so in some sense it wouldn't be unlike stopping say pneumonia treatment to remove a ruptured appendix; 2) Cipro barely biodegrades in both soil and water (up to 29 days in freshwater and longer, could be slightly shorter in saltwater), giving the nem a short break shouldn't make a difference; 3) the treatment protocol is largely anecdotal, we don't know if the treatment period should last 3-6-9 or 12 days or for that matter if 100-250-500mg of cipro are equally effective

 

[dbraun15]

I'd generally agree but for 3 considerations to keep in mind: 1) pump failure caused the deterioration not the treatment, so in some sense it wouldn't be unlike stopping say pneumonia treatment to remove a ruptured appendix; 2) Cipro barely biodegrades in both soil and water (up to 29 days in freshwater and longer, could be slightly shorter in saltwater), giving the nem a short break shouldn't make a difference; 3) the treatment protocol is largely anecdotal, we don't know if the treatment period should last 3-6-9 or 12 days or for that matter if 100-250-500mg of cipro are equally effective

I agree about the unknown and it being anecdotal. Most of the success stories have treated for 7 days and generally if treated again, the lower the efficiency of the meds. I'd just be worried about stopping treatment and infection gaining a stronger hold. Great discussion! The best thing is that we're all trying to help and hope the nem pulls through.

 

[Cnidoblast]

Any signs of bleaching? I would think ciprofloxacin would be harsh on the symbiotic algae

 

[Christopher Davis]

None at all

Any signs of bleaching? I would think ciprofloxacin would be harsh on the symbiotic algae[/QUOTE

 

[Christopher Davis]

Well #%^* observing now... looks like my heater was unplugged. 2 strikes the water didn’t get super cold but I feel it got cold enough... brought the temp slowly back up. Not looking good starting to fear the worst.
Still sticky to the touch. Mouth is closing slowly.

 

[Cnidoblast]

I guess the DNA Topoisomerase of the algae must be different enough that the drug does not bind... Interesting

 

[Cnidoblast]

What's that white stuff - bleached tissue??
http://aac.asm.org/content/50/5/1664.full seems to point to cipro causing mitochondrial dysfunction at high doses
Might be worth halving the dosage and doing a waterchange at this point in time

 

[EmdeReef]

Well #%^* observing now... looks like my heater was unplugged. [emoji20] 2 strikes the water didn’t get super cold but I feel it got cold enough... brought the temp slowly back up. Not looking good starting to fear the worst.
Still sticky to the touch. Mouth is closing slowly.

Is this pic after a water change?

 

[Christopher Davis]

Is this pic after a water change?

Yes

 

[Christopher Davis]

What's that white stuff - bleached tissue??
http://aac.asm.org/content/50/5/1664.full seems to point to cipro causing mitochondrial dysfunction at high doses
Might be worth halving the dosage and doing a waterchange at this point in time

That’s it’s mouth, the only color in the anemone is located on the oral disk which is blue.

 

[Christopher Davis]

What's that white stuff - bleached tissue??
http://aac.asm.org/content/50/5/1664.full seems to point to cipro causing mitochondrial dysfunction at high doses
Might be worth halving the dosage and doing a waterchange at this point in time

That’s it’s mouth, the only color in the anemone is located on the oral disk which is blue.

 

[Cnidoblast]

There is still a possibility of the antibiotic causing stress to the animal - running some carbon for a day should not hurt as cipro lasts in tissue for quite some time - I think the reaction is caused by the waterborne cipro as it can activate sensory receptors

 

[EmdeReef]

That’s it’s mouth, the only color in the anemone is located on the oral disk which is blue.

Doesn’t look bleached at all. Hard to miss when it happens.

 

[EmdeReef]

Yes

Still attached though? Give it a few hrs.