You will notice pressure changes if there is a change in temperature. If there is no ambient air temp change around the cylinder and the pressure is dropping, than that means it is near empty. The co2 is a liquid in there. Once it is all gone, all that is left is the gas and if it is loosing pressure that means it is running real low. I usually just swap out once the pressure starts dropping. Once it turns into the gas only stage is when it starts dropping pressure so the end is extremely near depending on your bubble count.