It depends on the actual size of the sand bed. IME, most "refugiums" are just too small to have much effect.
When I had a 4' eel in a 150DT/50 sump the nitrates were uncontrollable until I added a 6-8" DSB, but I used a old 120g tank to put it in. It did a great job for me, reducing nitrates from untestably high to <10ppm or so within a month or two.
I don't know that I'd bother with much over8" or so - the effect will be pretty much the same with either and you'll be buying (and carrying, cleaning) 1/2 the sand.