Originally, my fish room/laundry room (13'x17') just had a 75g basement sump plumbed for my 180g on the 1st floor for ease of maintenance, room for equipment and hide all the mess and uglies.
I had built a 2"x4" stand for the sump and added an empty 102g tank that I had to the top of the stand just for extra water volume and isolation purposes, this also facilitated for easy water changes without shutting down the sump and main tank. After a few months, addiction turned this into a full blown reef tank. Then because I had enclosed this fish room with a wall and door, I told myself that having a counter height cutout in the wall for my empty 120g would be nice and I'll leave it empty for future use. This ended up being a full blown SPS dominate system with it's own 30g sump. Then I saw someone selling a 30" cube and since I never owned a cube tank, it ended up in the middle of my fish room plumbed to the SPS system for frags and overflow coral.
So in short, the fish room had a lot of saltwater and I thought I had it figured out beforehand with an inline exhaust venting via a humidistat (which was on almost 24/7). There were fans blowing across the top of all 3 tanks, when the 12k BTU AC was not cooling, it was on dehumidifying mode from April through November and there was a dedicated dehumidifier on the other side of the fish room on at all times (I left the door to the fish room always open unless we had guest) yet the semi-finished basement and adjacent fish room always felt damp vs the 1st floor.
As the years went by, all my tools or anything metal showed signs of rust. There are some painted poured concrete walls and on one wall where there was a sink countertop layout, mold was growing behind on the wall and eventually onto the wood of the cabinets. On this wall, the mold actually ran up to the 1st and 2nd floor. I did not even notice this till I had to break down the entire fish room.
I took 2 years off after this because it was a monumental feat for me to sell all the livestock, shutdown the tanks and clean them out as best as I could. My 180g was still on the 1st floor so this past April, I started it back up but utilized a sump in the stand vs plumbing anything back into the basement. Now the basement is relatively always dry. The inline exhaust is no longer needed but the dehumidifier is still utilized.
My 1st floor has the 180g + sump, a 24g + sump and a 65g AIO tank. Area is probably only 600~700 sq ft but no way does it feel how the basement once was, always damp. Whether there is better airflow or not, having the tank and sump on my 1st floor has actually worked out better since it's always been a "dry" house. Even with these 3 tanks running, the 1st floor averages about 46% humidity since I set the tanks back up in April. I couldn't get the humidity below 60% in the fish room. I do run central AC for the 1st/2nd floor so that is a major factor too.
I'm sure being below grade and on a hill with underground streams has a lot to do with the issues I've encountered so not saying that I would never do a basement sump again but it would have to be in a different house and the basement would need to be above grade for me to consider it.