I suppose you could in conjunction with turning off equipment such as your skimmer and ATO. That is always an option, but the DOS has the capability to run one pump in reverse to simultaneously do it, which is still, with regards to my last comment, my preferred method. As to how long it will take, the pump is capable at running at different speeds indicated by a different mL/min ratio. In all actuality, you could remove 4500 mL in just a few minutes, then replace it a few minutes later, as long as your pumps remain calibrated and your NSW matches salinity of your OSW. Choose your journey.