Long term Nopox user here... at least for the past eight years.

On my previous 150gal tank I used to dose just 18ml daily and that was enough to keep NO3 and PO4 at undetected levels using Salifert test kits.
Four years ago I upgraded to a 180gal tank and I thought 20ml of nopox would suffice to keep NO3 and PO4 at the same levels but to my surprise I need 24ml daily despite having a similar bioload and equipment. In my case the high dosing of NOPOX is due to the use of a 55w UV sterilizer, as UV helps exporting nutrients by killing large amounts of bacteria (exported via skimmer) which in turn depletes Potassium (bacteria uses some potasium).
To keep things stable on my tank I have been dosing 24ml of NOPOX and 12ml of Potassium daily ( I keep Potassium at 400ppm). So, every tank is different and it is hard to tell what is the correct dosage. I am happy as far as it is not negatively affecting corals or fish.