Good questions....if you don't have any live stock yet (inverts, fish, corals) you probably can do a 10% water change a week.....it really depends on how much bio load you have, what your filtration looks like (chemicals, Skimmer, etc) and what your Nitrates and Phosphates looks like....My 29 has been up and running since Dec 27, small bio load so far, and I use Chemi Blue and Purigen for my chem filter, and have a small skimmer.....right now my phosphates are at a 0, nitrates don't seem to high, so I stick with about a 10 percent change a week (2.5 to 3 gallons).