I would, and have used it 'inside' the water area - i.e. in the sump where leaks drip into the sump. I don't think the flex-PVC tightens up against the barbs as well as vinyl tubing so I would not use it in the normal plumbing areas under the tank where any water drips would drip into the cabinet. (And yes, I used hose clamps on the flex-PVC and it still had small drips in the line.)