Take this as just my experience but I try not to medicate if I don't have to. If the fish are stressed from the high nitrates, they are more susceptible to disease and parasites. I would do a series of as large a water change as you can to get the nitrates down. If you can do a 90% water change I would. If you only do a 50%, you'd need to do 3 50% to get down to 10ppm. But I'd get the parameters in order to reduce stress. While you're at it, it wont hurt to do the hyposalinity. The biggest thing in my opinion is keeping the fish eating. If they stop eating, then I would try to add some garlic oil to the food. It will encourage them to eat it and help keep them feed. Once the stress is gone, they should be able to fight off the ich better. I'm not a fan of copper if I can help it. I managed to save a single leopard wrasse from a 120G tank full of fish that got red velvet once, so it definitely has it's uses and I'd keep it on hand. Again, this is one random guy on the internet's experience. I'm definitely not an expert.