When handling most types of anemone that you can get for your home aquarium, like many people have already said, their sting isn’t really strong enough to effect human skin. But it really does depend on the person. Most people have thick enough calluses on the palm of their hands that an anemone that you would get from your average pet-store can’t sting through it. But it’s the back of your hands and open cuts or sores that you need to be cautious about, because there is nothing to protect your nerves from getting stung. But as I said before, it depends on the person. I’ve worked with commercial aquariums for about 2 years now, and because of all of the glass and rocks and things like that that I work with, and have scar tissue and calluses all over my hands. Because of that I have worked with and interacted with tens of different types anemones big and small (and HUGE) with my bare hands, without an issue. So it is completely up to your judgement to decide. But don’t feel inclined to handle them barehanded just because you can, if you are unsure (or if you are prone to finding out new allergies that you have that you didn’t know about before) than it couldn’t hurt to just put on a pair of gloves as a precaution.