Is it safe to use medications to proactively treat these fish before adding it to the main tank, or should I just watch and monitor? I was planning on using Prazipro and Cupramine. Thank you in advance for the help!
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Cowfish should be fine with Prazipro; but there is some debate as to whether or not they are copper intolerant. The confusion arises from their close association with puffers, a known copper sensitive species. I've never owned a cowfish, so I cannot say from personal experience. However, I know they have a thin slime coat so any external parasites should become apparent on them. Or alternatively, you can safely use tank transfer method, Chloroquine phosphate or hyposalinity.
I have one instance that required cupramine treatment (per recommended dosage) for my boxfish, and he came through without an issue.

