hi Dom i checked this out for you. APi kits are know to be the same regents for freshwater and saltwater, they are unsure of red sea kits. but using a salt water for freshwater may in some cases throw you results off, with PH, but this also depnds if you use freshwater test kits for salt or saltwater for fresh, you may find your results from tests either way you do them, could be well out! as the paramitors bewteen salt and fresh is vastely different, i would NOT use a freshwater test kit on the salt water just to be safe. but this is what i have read about, and asked a friend who has freshwater tank. but im new to this marine hobbie, so i would advise going down to your local marine store as they usally have more of wealth of knowledge