Both in the water or the metro in the food? I wouldn't do it, simply because I've never mixed them before and their efficacy overlaps (both anti-protozoals). The chloroquine is more effective, but you need to be careful about dosing. Run a Google search on "Hemdal Chloroquine" there is an article I wrote about 10 years ago. Please note that I've since revised my dosing downwards as I was seeing too many cases of bad reactions in wrasse and lionfish. I've stopped using it altogether because the material I had was out of date, and then, due to people taking it for covid (!?) it was pulled from the US aquarium market.
Jay