Agree with the need for an air stone placed near the bottom of the tank, multiple stones in large tanks. Since home aquarists typically don't have dissolved oxygen meters, you need to err on the side of caution and aerate strongly when dosing certain drugs like Prazipro.
What happens with Prazipro is that it is 95% glycol. This is attacked by bacteria as a food source (as is the 5% prazi as well). That bacterial action consume oxygen from the water and produces carbon dioxide. Those must be balanced by proper aeration.
Finally, a protein skimmer can be used as an aeration source in many aquariums, but you do not want to collect skimmate while dosing prazi.