I'm not a fan of disturbing the bed. It depends on the method of sandbed you are running though. I run the "super alive" style, where I want tons and tons of worms and bugs and critters all driving around through it, constantly stirring it up by microscopic motion. Yep, there is some detritus in there, but I notice that as it builds up, my bug population increases, and the problem is generally self healing.
I love seeing a hundred spaghetti worms all stick their tentacles out when I feed the tank, and the great eruption of nassarius snails all emerging from the bed at once.
If you vacuum, it ends up killing alot of stuff. Stuff I specifically want alive. So I try to not disturb them, and they reward me by keeping my sand from clumping.
If you have a particularly large tank (250+) you could run a tiger tail cucumber. If you have larger grain size sand, a conch would work too. (It's fun with 1-2mm grain size to watch them pick up each grain one at a time and clean it, then set it down and grab the next one)