Many people change a section of their sand bed out regularly i myself change nearly 100% of my sand bed in my nano every 3 months and in my previous larger reef before that i changed about 30% every 3 to 4 months and have done so for the past 18 years and see nothing but positive results from the method, it is an excellent export and refreshing mechanism helping towards preventing old tank syndrome
On a sand bed that is deeper or sat for a long time a VERY cautious approach is required as a lot of nasties will potentially have built up that you don't really want to disturb into the water column which is one of the reasons why deep sand beds fell out of favour and are often referred to as ticking time bombs, despite what many believe they do have a finite lifespan even with maintenance and will at some point require intervention/refreshing or at some point it will reach critical mass as it were
Personally i advise people determined to run a DSB to run it in the sump in two separate tubs that way every 3 years a tub can be pulled and replaced with fresh sand so in that way it never reaches critical mass and can be run indefinitely on this rotation method and doesn't become problematic
BRS had issues because they unbalanced the system by trying to remove and not replace and go bare bottom that is one of the reasons they are very much pro sand bed now
Here is my nano that i suck the used smelly discoloured sand out with a hose and replace with glorious bright white sand every 3 months
And i use this tube with half a pop bottle to put the sand in right to the bottom exactly where i want it to go with no mess