My first 4k will be delivered next week! I have a 150 with a single center overflow. For now, with just 1, I will put horizontal on one end...but my thought when I get the 2nd is to have one vertically on both back corners. Running one in forward while the other is in reverse and the gyre direction every couple minutes. Have you tried this?
When vertical do they stir up to much of yhe sandbed....or not enough?