I would have to definitely say yes. I have a 120 gallon tank with a CPR overflow box on it and an aqua lifter. It essentially takes the water from the tank pulls it over the lip into the overflow box and then down below I have a 40 gallon sump. My tank is not drilled just a regular standard 120 tank
It's possible but personally not worth it in areas where power outages are likely/frequent. Better off to just drill the tank or purchase one predrilled