Cipro works, I just finished the treatment on two nems. A "Ritteri" and a Haddoni. They are now both looking incredible. Use a ten gallon as instructed. As for the water changes, change as much as you can, a full 10 every day to start, if possible, but at least 5 gallons per day after the nem has stopped releasing stuff into the water. I also dosed 250 mg. every twelve hours instead of every 24, even knowing that the light breaks it down. My Ritteri now looks amazing, is huge and is even getting glowing tentacle tips at night.