Ok so reading more about the relationship of nopox and gfo together is it can be done BUT you must monitor it very closely to not hit 0/0 on both. And if I happen to hit 0/0 I have NeoNitro and NeoPhos on hand.
I’ve used Nopox for over 3 years and it’s very good for nitrate reduction but not so good for reducing phosphate levels. You also need to wet skim
Many of us have to use GFO in addition, I personally use rhowaphos in a reactor and keep phosphate locked down at around 0.03ppm so very low and if you can do this you will avoid many algae and other issues.
But, you don’t want zero nitrate, or again you may encounter problems and also starve your corals and personally I target around 10ppm nitrate, but I’m currently at around 18, so the Nopox dose is increasing.
It’s just a balancing act with Nopox and you will soon get used to it. I’m currently dosing 32ml/day (in about 550 litres/145 USG) which is around double the maximum recommended dose (raised very slowly and carefully monitored) but, well, I like fish so.......
I think in summary, if your trying to reduce phosphate alone, I personally wouldn’t use Nopox as the method, I would use GFO and maybe Nopox at a low maintenance dose to keep nitrate in check. And if nitrate is to low, maybe add a few more fish.
And if my Hanna phosphate reads zero, I am delighted because it has a +/- error margin I think around 0.04, so it will just be very low because of the amount of live stock.