Curious - why enrofloxacin. The reason I ask is that using fluoroquinolone antibiotics can worsen antibiotic resistance - and I would not want to spread resistance. However, medication like kanaplex - is not really used much anymore - (an aminioglycoside) - and resistance would be less an issue IMHO
I only suggested enrofloxacin due to the speed in which it works. (5-7 days) as opposed to some slower working ones like kanaplex which are 10-14 day treatments. I'm also not sure on the kanaplex dosing. It doesn't seem to agree with the fish disease book by Noga. But that is also why I was hoping Jay would respond. He knows much much more about fish antibiotics than I do.
most external bacterial infections on a fish will be gram-negative. Enrofloxacin and kanaplex both work on gram-negative bacteria.
according to Noga, kanamycin sulfate (kanaplex) should be dosed, for prolonged immersion at 50mg-100mg per liter. Every 3 days, for 3 treatments. (10) days. Now keep in mind, that is dosing pure kanamycin sulfate. kanaplex, which is seachem's version, is only 32% kanamycin sulfate. its only 32% pure.
Active ingredients: kanamycin sulfate (32%)
Inactive ingredients: excipients (68%)
Kanaplex comes in a 5g tube. of which only 32% is kanamycin sulfate. So only 1.6 grams of kanamycin sulfate per tube. 3.4 grams of something else, per tube.
According to Noga, my 20G QT tank, containing 16 gallons of water (72 Liters) would need a dose of 50mg/Liter or 3.6g up to a dose of 100mg per liter or 7.2g. Dosed every 3 days, for 3 doses. Wouldn't that take 2 to 4 tubes per dose? times 3 doses? 6 to 12 tubes of kanaplex? At like $8 a tube?
and yet the kanaplex label by seachem recommends much much less than this amount. Who is/was right? Noga or Seachem on the dosage? A lot of Seachem's other claims aren't exactly backed up by science either, so I would not be surprised to find out this one isn't either...
regardless, Endofloxacin works faster and seems easier/more straight forward to dose, so that is the one I recommended.
Endofloxacin dosage is 9.5mg - 19mg per gallon. That works out to 150mg to 300mg per dose for my 72L QT tank.
A nice and easily manageable amount.
Would love to be educated on this though. I don't understand why the dosage recommendation by Noga is so different than that recommended by Seachem.