Cons/Side Effects - Appetite suppression and lethargy are both common side effects. If a fish stops eating, start doing water changes (lowering the copper concentration) until he eats. If this happens a second time after you resume raising the copper, you’ll know you’ve encountered a “copper sensitive” fish and an alternative treatment should be used instead. (Note: Anytime you lower the copper level below therapeutic, the 30 day treatment clock begins anew once the copper is raised back up.)