If you use the calculator on Bulk Reef Supply's website, it takes the guess work out of it. They even advise the max you want to raise each parameter per day. I'd dose manually until you get both the Calcium and Alkalinity where you want them. Then, can start dosing with your dosers. Once balanced, I've found that I dose the same amount of Alk and Calcium per day. I have a 55 gallon mixed reef with a lot of coral and a 3" Squamosa clam
I dose 88 ml of soda ash solution and 88 ml of calcium solution daily. I spread out the dosing in 10 minute intervals spread out over the 24 hours, and separate the alk dosing and Calcium dosing by an hour.