When I was dosing NoPox I followed the directions for a mixed reef to get the initial dose then cut it back to a 3rd and started there for the first week. I was testing both Nitrate and Phosphate every three days or twice a week I guess. After the first week I increased the dose and repeated measurements. I increased again and by about the 3rd week I started to see both Nitrate and Phosphates go down. So now I had numbers, checked my dose amount, adjusted based on the reading again for mixed reef and started week 4. By now Nitrates which started over 50 had dropped down to 5 ppm and Phosphates .06. By the time I was done Nitrates held steady at 5 ppm but Phosphates went to 0 using Hanna's checker. Knowing that was + or - I decided to stop and see what happens now when I don't dose or hold it in maintenance mode.
Nitrates more or less are holding steady but phosphates are slowing increasing but nothing that I'm personally concerned about at about .16 - .20. The stuff does work but everything I've read suggested to start slow and lower than what the instructions recommended. Take measurements twice a week, increase then repeat. You can dose at different times although I recall doing mine daily between 12 and 1 pm.