Chris,
I have a 30 gal cube tank that I used for QT. have 2 MP10 in it for circulation, open top, not glass cover. I have healthy fish died overnight in it due to hypoxemia. I solved that problem by put an air stone in the tank.
It does happen. There are a lot of other factors that compound or mitigated hypoxemia. Health of the fish, number of fish, how active fish are, is there anything else in the tank that consume O2. How much photosynthesis activity going on prior to the light goes out, thus how high the O2 is in the tank before the light goes out and a bunch of other factors.
It is not far fetch, IMO even likely, that MandaMarie's fish is killed with low O2 at night. It happened to me. The inverts and algae are totally unaffected. I use this tank to QT corals, clams and anemones. I don't QT fish. The pair of clown fish that died were a healthy pair of breeding clownfish that I have for long time. I keep them in there when I am trying to shuffle my pairs around. They were fat, healthy and were breeding. They did not died from disease. Here healthy eating up a storm the night before and dead without wound in the AM.