Rockskimmerflo. First of all I want to thank you for pointing out to me that my initial answer will not work for everyone. I am old, probably senile, have PTSD, and have been doing this for too long so some of my answers may not come off as well as I would like them to come off and I have been rightly accused of this occasionally. It's a fault in the way I am wired.
I also want to thank you for the long reply as most replies are like "Duh" or "OMG".
The PVC in my skimmer may be 30 years old but the trough above the water is only 10 years old. When I moved here to this new home I transferred everything in my old tank to a new tank here in a few hours. I didn't use ozone for maybe 4 or 5 months because the generator broke before I moved and I didn't get one here until recently. In that time I added many new fish and corals because this tank is larger and needed more livestock. (2 pipefish, spotted wrasse, anthius and a few others)
I don't need ozone, I just always had it since the stuff was first used in tanks and I like the idea. I am not even sure if it does anything and this generator I use now is only a third as powerful as the one I used for those decades.
If this one breaks, I may not replace it. It probably helps the inside of the skimmer stay clean but when I took the system down to move, I spent quite a while chopping worm tubes out of the body of the skimmer so I assume ozone does not affect them or maybe it accelerates their growth.
Last week I added a tiny yellow clown gobi. A few of days ago he got covered in parasites, probably ich. The spots fell off a couple of days ago to reproduce and the fish now has spots again. Nothing else is infected. I see this as a good sign because I want an inflow of parasites.
Of course this is my methodology and very few other people do this or feel this way. I also know it sounds weird but my fish never get sick except for maybe pop eye which is more of a mechanical thing and it is rare.
I think my method is very easy and cheap as no quarantine, hospital tanks or medications are ever needed but it can't be used in a store where new fish are constantly added as that is not a stable condition. It also will not work in a new tank where bacterial, viral and parasitic populations are also not stable.
Over the years many people have argued that it is the ozone in my tank that is the reason for the apparent immunity and I always tell them that if they think that is it, then why not use ozone.

I know it has nothing to do with it and it is the natural influx of parasites and diseases just like in the sea that keeps my fish immune.