Palytoxin tolerance?

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Now I'm not advocating anyone trying to do this (!!), but with palytoxin in the news so much lately, I was wondering if it is possible to build up an immunity/tolerance to the toxin. I've seen so many coral dealers using bare hands to handle corals of all kinds that they must be reaching into water that has at least been exposed to palythoas. Is it possible that they are unwittingly building a tolerance? Or could it be the opposite and becoming more susceptible? Just curious.
 
It is not a substance you can build a tolerance to. There isn't a cell that it doesn't kill and the LD50 is so low that it would be fairly hard to not just end up killing yourself while trying to "mildly" poison yourself.
In short, no, it doesn't work that way and it is a very very bad idea. My two experiences were horrible and I'll just say now for no one to try anything like that.
 
Skin exposure is generally fairly mild. Most of us old timers have developed standard practices that help insulate us from getting anything worse than minor skin exposure. Don't siphon aquarium water by mouth. I sucked up a bristle worm once... I promise, that'll never happen again. Don't stick wounded hands into a tank. Live through a few minor cuts becoming infected, and you learn not to do that anymore. Gloves... for some of us, I don't use them, but I do use tongs. I have surgical hemostats of various sizes and profiles, one set of rubbery plastic coated steel tongs, and several varieties of plastic salad tongs. I don't care for most of the specifically designed aquarium tongs, but kitchen and medical tongs work great. Make sure they're not coated in oil or something, and rinse them well after use. I keep 5 or 6 different sizes and types in a plastic shoe box, and use what is appropriate.

My number one rule in reefing: Patience. Nothing good in this hobby happens fast.

Number two: Keep your grubby mitts out of the dag blasted tank!
 
like that one guy who builds up a tolerance to snake venom?.. definitely not something i would want to try lol.
 
like that one guy who builds up a tolerance to snake venom?.. definitely not something i would want to try lol.

With a non protein substance like Palytoxin you can't give yourself an immunity to it. Some people have shown it with some venoms, but not with Palytoxin.
 
It wouldn’t work because palytoxin binds to nervous tissue forcing the sodium potassium pumps to depolarize, which makes your nervous tissue unable to send any sort of signal.

Its a long carbon chain molecule that has a lot of OH groups on it, not a protein, so our immune cells can’t target it (and build up an immunity). The only thing that works to get rid of it is for the toxin to sit in an acidic environment and undergo a few oxidation/reduction reactions which happen naturally. Takes the body about three days to process all the palytoxin it has been exposed to, which (so far) doctors can’t do anything to speed up.
 
Like already posted you can´t build up an immunity against Palytoxin. Reports of aquarists with repeated intoxications rather show the opposite, it seems to get worse with every intoxication, but it is hard to tell whether just the amount of Polytoxin increased or whether the affected persons got more sensitive to the poison.
 
Is there a way to test to see if your coral has this toxin?
 
Is there a way to test to see if your coral has this toxin?

If it's in the Genus Palythoa, Protopalythoa or Zoanthus, it harbors this toxin. There are varying concentrations from species to species and it's best to be as safe as you can with all of them.
 
If you have zoanthids in your tank, if you collect zoanthids and palythoa, your chances of exposure are high. It is a potent potent neurotoxin. You do not develop tolerance. Surfaces and objects, carpet, tools, clothes that get exposed can expose others beyond the aquarist to this chemical toxin. Pulmonary, cardiac and neurological symptoms can vary from mild to serious. Even potentially death. No joke folks.

Like a bad case of the flu and more.
But the damage it potentially does, with repeat exposures, is poorly studied. Damage to endothelial linings of lungs, GI tract and damage to cardiac myocytes is highly likely even under small single exposures to frequent hobbyist exposures in the marine aquariums we all keep.

Perhaps we need more research and documentation.
Some zoas and some palys (very common ones), have significant amounts of the toxin.
Wish there was someway to catalogue this.
Remove those in the hobby from collection.

Be aware You can be exposing your family, kids, grandchildren to these toxins as well as your pets. Also anyone doing construction, work around your home and around the reef tank especially to this serious toxin.
Some can get very sick, some can experience permanent damage and some can yes, even die.
 
We need more info about what many of our corals secrete and use as chemical warfare against each other. Palytoxins and other similar compounds may be present in many many of our prized pets we keep in our glass boxes.
 

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