I make up my water the same day I do a WC, about every two weeks. As a result my Ca and Alk drop a bit from precipitation since I keep two PH's running, one in the bottom for circulation, one at the top for aeration. Over time I have learned to use this to my advantage, and using an ounce each of Ca and alk supplements match it to my tanks #'s before I do the WC, so it doesn't skew my dosing.