I hard plumbed everything and use about 6" of oversized vinyl between the return pump and return plumbing to prevent flow restriction on the barb valve. For my drain, I have a herbie and used fixed plumbing (3/4"), but for the last foot of the drain, I used 3/4" loc-line to make it super easy to remove my filter socks (no contorting the filter sock and holder, simply move the drain out of the way).
The loc-line gives you the flexability that flex-pipe has, but it won't bend or move when you don't want it to like flexible tubing does. Definitely super cool. Props to MetroKat on nano-reef for giving me the idea.
Definitely go with a full-siphon drain if the sump is in a living area, it is so so so so much quieter. The Durso had me pulling my hair out with the constant bubbles - no matter how perfectly you tuned it, it STILL made a trickling sound.
While Schedule 80 looks super sexy, it is way more expensive and the inner diameter is smaller than schedule 40. If you can get black schedule 40 (you usually can online) I would go with that just for the cost aspect, I have never heard of anyone having pressure greater than schedule 40 can handle on a fish tank. Also, you can use schedule 80 fittings with schedule 40 pipe, so if you wanted a heaver fitting for a key area, you can get it.