Well, It may or may not be an issue, but as your reactors clog up, flow is reduced through them which will increase pressure and eventually flow rates on the return line. This will increase the amount of water going to the tank. Your main drain line is set to a certain flow. As this flow increases, you will have more flow going down your secondary drain which can lead to more noise. So to stop that you either swap out your media, or adjust your main drain valve. If you add a reactor or take one off line, the same issue develops.
For myself, even if the flow rates change slightly over a long period of time, it's just something I never want to deal with, Ever.