PraziPro Chemistry Activity time?

[FishFilet]

I’ve seen two answers to my question. PraziPro remains effective beyond 24 hours. While others say the only active ingredient after 24 hours is the polymer which isn’t the component that treats the parasites.

I understand already the second dose is lest effective. But I don’t understand or get how this inverse reality works. The first question is truly the most important for me to know.

Thank you.

 

[fishguy242]

#fishmedic

 

[sc50964]

This should move to fish disease section

 

[MnFish1]

I’ve seen two answers to my question. PraziPro remains effective beyond 24 hours. While others say the only active ingredient after 24 hours is the polymer which isn’t the component that treats the parasites.

I understand already the second dose is lest effective. But I don’t understand or get how this inverse reality works. The first question is truly the most important for me to know.

Thank you.

It is difficult to answer your question without reading the sources of what you're saying. I'm also not sure where the information comes that 'the second does is less effective'?

My understanding is that Prazipro does break down over time - usually considered about 72 hours. However, it is also rather quick to act. Maybe reading the current recommendations in the Quarantine procedures will help answer your questions?

The first dose kills the active flukes - the second dose is used to kill hatchlings. The third dose is used for susceptible fish again to make sure any living flukes that may have hatched are killed.

"
Day 35: Praziquantel Treatment #1

• Confirm copper has been removed adequately to drop the concentration to less than 1 ppm. Copper and Prazi should not be administered simultaneously.
• Add Prazipro to the QT per the instructions on the label.
• Ensure the additional oxygenation source is working. This treatment will potentially reduce the oxygen levels within the QT to critical levels without additional air flow.

Day 42, Day 49: Praziquantel Treatment #2, #3

• Add Prazipro to the QT per the instructions on the label, 7 days apart. Spacing needed for these treatments is based on killing new flukes hatching from previously laid eggs. The time interval is not well known. A range of 7 to 9 days seems to give the best results.

Day 64: New Fish QT complete

• Observe fish for 2 weeks after last prazi dose. Note: many public aquariums do not move fish out of quarantine unless they are in the middle of a full copper treatment. This vastly reduces the risk from Cryptocaryon or Amyloodinium. To use that method, substitute a copper treatment for this 2 week observation period, and move the fish out around day 10.
• Conduct a 5-minute fresh water dip if the fish is of a species particularly susceptible to Neobenedenia flukes. If flukes are detected, reduce QT salinity to 50% and hold for an additional 35 days.
• Confirm salinity and temperature of QT and DT are the same, add fish to DT."

 

[Randy Holmes-Farley Verified Community Expert]

Jay discusses this topic here:

Questions about Prazipro

I’ve researched a lot but can’t find definitive answers or any answer at all. I have dosed the first (of two) Prazipro treatment in my DT. Here is what I want to know : 1- When exactly can I turn my UV back on (in-between doses and after the second one)? 2- Same question for skimmer 3- When...

www.reef2reef.com

 

[FishFilet]

Thanks everyone.

 

[FishFilet]

I see Praziquantel is preferable. As it doesn’t grow bacteria that consumes the medicine.