Praziquantel water soluble?

[Humblefish]

I'm basically wanting to switch over from liquid Prazipro to a powder form of praziquantel. Like this: Praziquantel

The reason is I'm try to avoid the oxybispropanol found in Prazipro, which has caused bacterial blooms in my QT in the past - especially when mixed with other medications. I know powder praziquantel is "not easily water soluble", which is why it is suggested to mix it with a small amount of ethyl alcohol or even vodka.

But does that mean it flat out won't dissolve in water or it just takes a while to do so?

 

[Randy Holmes-Farley Verified Community Expert]

It is very poorly soluble in water. I doubt you can make a water only stock solution.

 

[Humblefish]

Not the answer I was looking for, but thank you Randy. :wink: Seems there's no getting around mixing alcohol with praziquantel. :sad:

 

[Randy Holmes-Farley Verified Community Expert]

Yes, that's presumably why it is done.

Happy reefing.

 

[Trickman2]

Randy, can you explain why Oxybispropanol cause bacterial blooms?

 

[Randy Holmes-Farley Verified Community Expert]

Randy, can you explain why Oxybispropanol cause bacterial blooms?

If it does, it’s presumably just because it is an organic carbon source/food, just like ethanol in vodka. [emoji3]

 

[Miami Reef]

Is the praziquantel in API general cure soluble in water? The packaging states to directly add into aquarium water.

 

[vtecintegra]

I can get GC to dissolve. I switched to prazi powder after flukes got through with GC. The straight powder is a pain. Vodka is fairly ineffective, and it takes a lot of DMSO to dissolve it.

 

[Miami Reef]

I can get GC to dissolve. I switched to prazi powder after flukes got through with GC. The straight powder is a pain. Vodka is fairly ineffective, and it takes a lot of DMSO to dissolve it.

Do you use DMSO to dissolve the prazi powder?

If the prazi in GC can dissolve, why wouldn’t straight prazi dissolve too?

 

[vtecintegra]

I had to use DMSO with the powder. It didn't seem like it would ever dissolve in salt water. But it takes a lot and killed my pH.

No idea why GC seems to dissolve much easier. I was treating all fish with it when going through quarantine. Would just add it with a little stir and it would dissolve. I'v wondered the same. Why is the powder so hard to dissolve, but GC doesn't seem to have that problem.