Hi, my tank is a 40 breeder. I have about 40 pounds of gulf live rock, and 40 pounds sand. Tank is around 8 months old. Ive been dosing bioptim and biodigest every 15 days and never had any issues. This time I added the reef booster and coral vits. Size was just the standard size amp. Corals are leathers, zoas, gsp, gorgonian, cup coral, and some filter feeders, some type of bivalve that came on my live rock I seen open and close every now and then, sponges, lots of macro algae. Also Ive never seen any special instructions for these products. It just says does them every 15 days.