My experience: I run it in a brs reactor. I started off with just about a cup of it. I measured my po4 everyday when I first started. Once my po4 started to level off, I made adjustments from there. First adjustment was to open the small inlet valve on the reactor a bit more for a little more flow. When the po4 level failed to creep down further, I just added a little bit more gfo to the reactor, then continued to measure on a daily basis. Once my level of measured po4 (using the Hanna ULR) was where I wanted it to be, in the .03 to .06 range, I just kept everything the same. I will take a po4 reading about every 3 or 4 days to check how everything is going. Once readings start to creep back up, I just replace the exact amount of gfo.