I don't think so, primer is absolutely neccessary, drain pipe or not. If you are using it without primer, the fitting can sometimes pop right out. If you plumb a drain pipe in a house with no primer, it will fall right out and make an evil mess. Ive been able to pull pipes right out of the fitting when they were put in place a few years ago by an unqualified plumber, no primer, just the glue. A primer/glue kit at HD is 7 bucks, that will do it. Also, you can get clear primer if you know you will drip it. I personally wrap the pipe in masking tape before applying primer, but only if the fitting can be seen.