I have a 75 gallon bean animal supplied with a neptune cor 20 (2000 gph). I tested the pump wide open, and was handling the flow with a 1.25 inch drain. I backed down to half the flow, not because of drain problems, but because of bubbles getting back to the return pump, but...
I also need to say that my 1.25 inch supply splits into two 3/4" locklines, so that undoubtedly has an impact on my flow rate.
Also, the drain was working as designed, but it was louder than I wanted (until I backed it down to half). Based off of what I saw on my tank, if you want to run that many GPH, I would do two overflows with 1.25" drains. I feel like that will be quieter than a single drain with 1.5" drains, but that is just a guess.
The only concern with doing a 1.5 inch drain is the possibility that you may not be able to get the velocity of flow in your siphon to push all of the air out. If that were to happen, the silent operation of the Bean Animal is lost. As an added precaution, you could do the secondary and emergency as a 1.5" drain, but keep the primary at 1.25. - Again, this is just me guessing based off of what I learned on my own aquarium.